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Asian-Australas J Anim Sci > Accepted Articles
DOI: https://doi.org/10.5713/ajas.20.0429    [Accepted] Published online October 13, 2020.
Profiling of skeletal muscle tissue for lncRNAs related to muscle metabolism in the QingYu pig at the growth inflection point
Jia Luo1,2  , Linyuan Shen1,3  , Mailin Gan1,3  , Anan Jiang1,3  , Lei Chen1,3  , Jideng Ma1,3  , Long Jin1,3  , Yihui Liu4  , Guoqing Tang1,3  , Yanzhi Jiang5  , Mingzhou Li1,3  , Xuewei Li1,3  , Shunhua Zhang1,3,*  , Li Zhu1,3,* 
1College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, China
2College of Animal Science and Technology, Southwest University, Chongqing, China
3Farm Animal Genetic Resource Exploration and Innovation Key Laboratory of Sichuan, Chengdu, China
4Sichuan Province General Station of Animal Husbandry, Chengdu, China
5College of Life Science, Sichuan Agricultural University, Ya’an, China
Correspondence:  Shunhua Zhang,Email: zhangsh1919@163.com
Li Zhu, Tel: 13982083385, Fax: 13982083385, Email: zhuli7508@163.com
Received: 22 June 2020   • Revised: 9 September 2020   • Accepted: 28 September 2020
Abstract
Objective
s: Investigation of muscle growth at different developmental stages is an appropriate strategy for studying the mechanisms underlying muscle development and differences in phenotypes. In particular, the muscle development mechanisms and the difference between the fastest and slowest growth rates. Methods: In this study, we used a growth curve model to fit the growth inflection point of QingYu pigs and compared differences in the lncRNA transcriptome of muscle both at the growth inflection point (IP) and plateau phase (PP). Results: The growth curve of the QingYu pig had a good fit (R2=0.974) relative to a typical S-curve and reached the IP at day 177.96. At the PP, marbling, intramuscular fat and monounsaturated fatty acids (MUFAs) had increased significantly and the percentage of lean muscle and polyunsaturated fatty acids (PUFAs) had decreased. A total of 1199 mRNAs and 62 lncRNAs were differentially expressed at the IP compared with the PP. Additional to Gene Ontology and KEGG pathway analyses, these differentially expressed protein coding genes were principally related to muscle growth and lipid metabolism. Conclusion: Our results suggest that the identified differentially expressed lncRNAs, could play roles in muscle growth, fat deposition and regulation of fatty acid composition at the IP and PP.
Keywords: lncRNA; Growth Curve; Inflection Point; Muscle; Metabolism; QingYu Pig
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