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Asian-Australas J Anim Sci > Accepted Articles
DOI: https://doi.org/10.5713/ajas.20.0220    [Accepted] Published online July 2, 2020.
Excessive dietary lead reduces growth performance and increases lead accumulation in pigs
Hyunjun Choi1  , Sang Yun Ji2  , Hyunwoong Jo1  , Minho Song3  , Beob Gyun Kim1,* 
1Department of Animal Science and Technology, Konkuk University, Seoul 05029, Korea
2Animal Nutritional Physiology Team, National Institute of Animal Science, Rural Development Administration, Wanju 55365, Korea
3Department of Animal Science and Biotechnology, Chungnam National University, Daejeon 305764, Korea
Correspondence:  Beob Gyun Kim, Tel: +82-2-2049-6255, Fax: +82-2-455-1044, Email: beobgyun@naver.com
Received: 10 April 2020   • Revised: 20 May 2020   • Accepted: 26 June 2020
Abstract
Objective
The objective of this study was to investigate the influence of dietary lead (Pb) supplementation and feeding period on growth performance, organ weight, and Pb accumulation in pigs.
Methods
In a 56-day feeding experiment, a total of 48 barrows with initial body weight 10.4±0.6 kg were allotted to 2 dietary treatments (0 and 200 mg/kg of supplemental Pb) in a completely randomized design with 6 replicates. Body weight and feed intake were recorded to calculate growth performance. At the end of each 14 day-period (on days 14, 28, 42, and 56), an animal was randomly selected from each pen and slaughtered to collect blood samples, hair samples, left 5th rib, heart, liver, kidneys, lungs, and longissimus dorsi muscle samples.
Results
Average daily gain and average daily feed intake were reduced (p<0.05) by supplemental Pb during the days 42 to 56. Relative kidney weight to body weight was linearly increased with increasing feeding period in pigs fed the Pb-supplemented diet, but not in pigs fed the control diet (p<0.05). The Pb concentrations in hair, left 5th rib, kidneys, and lungs were linearly increased with longer feeding period in pigs fed the Pb-supplemented diet, but not in pigs fed the control diet (p<0.01).
Conclusion
Dietary Pb supplementation caused growth retardation and Pb accumulation in most organs, particularly in hair, bone, and kidneys in a time-dependent manner.
Keywords: Exposure Time; Lead Accumulation; Organ; Swine; Tissue; Toxicity


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