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Asian-Australas J Anim Sci > Accepted Articles
DOI: https://doi.org/10.5713/ajas.19.0140    [Accepted] Published online October 21, 2019.
Hot melt extruded-based nano zinc as an alternative to the pharmacological dose of ZnO in weanling piglets
Seung min Oh1  , MinJu Kim1  , Abdolreza Hosseindoust1  , Kwang Yeol Kim1  , Yo Han Choi1  , Hyung Bin Ham1  , Sung Jun Hwang1  , Jun Hyung Lee1  , Hyun Jong Cho1  , Wie Soo Kang1,*  , Byung Jo Chae1,* 
1Gyeongbuk Livestock Research Institute, Yeongju, 63052, Korea
2Department of Animal Resources Science, College of Animal Life Sciences, Kangwon National University, Chuncheon, 24341, Korea
3Swine Division, National Institute of Animal Science, Rural Development Administration, Cheonan 31000, Korea
4College of pharmacy, Kangwon National University, Chuncheon, Gangwon 24341, Korea
5Department of Bio-Health Technology, College of Bio-Medical Science, Kangwon National University, Chuncheon, 24341, Korea
Correspondence:  Wie Soo Kang,Email: kangwiso@kangwon.ac.kr
Byung Jo Chae, Tel: +82-33-250-8616, Fax: +82-33-244-4946, Email: bjchae@kangwon.ac.kr
Received: 19 February 2019   • Revised: 19 May 2019   • Accepted: 10 October 2019
Abstract
Objective
This study was conducted to investigate the effects of hot-melt extruded ZnO nano-particles (HME-ZnO) as an alternative for P-ZnO on growth performance, nutrient digestibility, Zn bioavailability, intestinal microbiota, and intestinal morphology of weanling pigs.
Methods
A total of 450 piglets (Landrace × Yorkshire × Duroc) were randomly allotted to five treatments based on initial body weight and sex. The experimental diets were fed in a meal form as phase 1 from d 0 to 14 and phase 2 from d 15 to 28. Treatments were the control diet without ZnO supplementation, the diet containing 2,500 ppm Zn as ZnO, and three diets containing 500, 1,000, or 2,500 ppm Zn as HME-ZnO.
Results
The overall result showed a higher (p<0.01) average daily gain in weanling pigs fed ZnO-supplemented diets in comparison to the control diet. There was a decrease (p<0.01) in fecal score in the ZnO-supplemented diets. Dietary supplementation of ZnO improved (p<0.05) crude protein digestibility. The weanling pigs fed the P-ZnO diet had a lower (p<0.01) Zn digestibility in the feces than HME-ZnO supplemented treatments. Weanling pigs fed diets supplemented with ZnO had greater (p<0.05) Lactobacillus spp. populations and lower Clostridium spp. (p<0.05) and Coliforms (p<0.01) populations in the ileum. Weanling pigs fed diets supplemented with increasing concentrations of HME-ZnO linearly decreased Clostridium spp. (p<0.05) and Coliforms (p<0.01) in the ileum. Lower (p<0.05) Clostridium spp. and Coliforms counts in the colon were observed in pigs fed with ZnO-supplemented diets. Weanling pigs fed diets supplemented with ZnO showed a greater (p<0.01) villus height in the duodenum.
Conclusions
Dietary supplementation of HME-ZnO and P-ZnO showed a potential to improve the digestibility of protein, intestinal Coliform and Clostridium, villus height in duodenum and ileum. Moreover, HME-ZnO showed a higher Zn digestibility compared with P-ZnO.
Keywords: Nano Zinc; Villus Height; Microbiota; Weaned Pigs; Bioavailability


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