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Asian-Australas J Anim Sci > Accepted Articles
DOI: https://doi.org/10.5713/ajas.19.0392    [Accepted] Published online August 26, 2019.
Effects of dietary Antrodia cinnamomea fermented product supplementation on antioxidation, anti-inflammation, and lipid metabolism in broiler chickens
M. T. Lee1  , W. C. Lin1  , Li-Jen Lin2  , S. Y. Wang1  , S. C. Chang3  , Tzu-Tai Lee1,* 
1Department of Animal Science, National Chung Hsing University, Taichung, 402, Taiwan
2Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, 404, Taiwan
3Department of Forestry, National Chung Hsing University, Taichung, 402, Taiwan
4Kaohsiung Animal Propagation Station, Livestock Research Institute, Council of Agriculture, 912, Taiwan
5The iEGG and Animal Biotechnology Center, National Chung Hsing University, Taichung, 402, Taiwan
Correspondence:  Tzu-Tai Lee, Tel: +886-4-22840366, Fax: +886-4-2286-0265, Email: ttlee@dragon.nchu.edu.tw
Received: 11 May 2019   • Revised: 17 June 2019   • Accepted: 11 May 2019
Abstract
Objective
s: This study was investigated the effects of dietary supplementation of Antrodia cinnamomea fermented product on modulation of antioxidation, anti-inflammation, and lipid metabolism in broilers.
Methods
Functional compounds and in vitro antioxidant capacity were detected in wheat bran (WB) solid-state fermented by Antrodia cinnamomea for 16 days (FAC). In animal experiment, 400 d-old broiler chickens were allotted into 5 groups fed control diet, and control diet replaced with 5% WB, 10% WB, 5% FAC, and 10% FAC respectively. Growth performance, intestinal microflora, serum antioxidant enzymes and fatty acid profiles in pectoral superficial muscle were measured.
Results
Pretreatment with hot water extracted fermented product (HFAC) significantly reduced chicken peripheral mononuclear cells (cPBMC) death induced by lipopolysaccharide (LPS) and 2,2'-Azobis(2-amidinopropane) (AAPH). Birds received 5% and 10% FAC had higher weight gain than WB groups. Cecal coliform and lactic acid bacteria were diminished and increased respectively while diet replaced with FAC. For FAC supplemented groups, superoxide dismutase (SOD) activity increased at 35 day only, with catalase (CAT) elevated at 21 and 35 day. Regarding serum lipid parameters, 10% FAC replacement significantly reduced triglyceride (TG) and low-density lipoprotein (LDL) level in chickens. For fatty acid composition in pectoral superficial muscle of 35-d-old chickens, 5% and 10% FAC inclusion had birds significantly lower saturated fatty acids as comparing with 10% WB group. 5% FAC diet would have higher degree of unsaturation, followed by 10% FAC, control, 5% WB and 10% WB.
Conclusion
In conclusion, desirable intestinal microflora in chickens obtaining FAC may be attributed to the functional metabolites detected in final fermented product. Moreover, antioxidant effects observed in FAC were plausibly exerted in terms of improved antioxidant enzymes activities, increased unsaturated degree of fatty acids in chicken muscle and better weight gain in FAC inclusion groups, indicating that FAC possesses promising favorable mechanisms worthy to be developed.
Keywords: Antrodia cinnamomea; Broiler Chickens; Antioxidant; Microflora; Fatty Acids


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