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Asian-Australas J Anim Sci > Accepted Articles
DOI: https://doi.org/10.5713/ajas.19.0274    [Accepted] Published online August 26, 2019.
Effects of compound organic acid calcium on growth performance, hepatic antioxidation and intestinal barrier of male broilers under heat stress
Junna He1  , Lianxiang Ma1  , Jialing Qiu1  , Xintao Lu1  , Chuanchuan Hou1  , Bing Liu1,2  , Dongyou Yu1,* 
1College of Animal Science, Key Laboratory of Animal Nutrition and Feed in East China, Ministry of Agriculture, Zhejiang University, Hangzhou, China
2State Key Laboratory of Food Science and Technology, and Synergetic Innovation Center of Food Safety and Nutrition of Jiangnan University, Wuxi, Jiangsu Province, 214122, China
Correspondence:  Dongyou Yu, Tel: +86-571-88982107, Fax: +86-571-88982107, Email: dyyu@zju.edu.cn
Received: 3 April 2019   • Revised: 11 June 2019   • Accepted: 11 August 2019
Abstract
Objective
The aim of this study was to evaluate the effects of compound organic acid calcium (COAC) on growth performance, hepatic antioxidant status and intestinal barrier of male broilers under high ambient temperature (32.7 ℃).
Methods
Nine hundred healthy one-d-old Cobb-500 male broiler chicks were randomly assigned into three groups with six replicates of 50 birds each. A basal diet supplemented with 0% (Control), 0.4% and 0.8% COAC, respectively were fed to birds for 6 weeks. All treatments were under high ambient indoor temperature of 32.7 ℃, and had a constant calcium and available phosphorus ratio.
Results
The results showed that, compared with control, the average daily gain (ADG) of broilers in 0.4% and 0.8% was significantly increased and the ratio of feed to gain (F/G) in in 0.4% and 0.8% was significantly decreased at 1 to 21, 22 to 42 and 1 to 42 days of age (P < 0.05). Compared with control, 0.8% COAC slightly decreased (P = 0.093) the content of malondialdehyde (MDA) in liver at 42 days of age while 0.4% COAC significantly decreased (P < 0.05) the activity of alkaline phosphatase (AKP). Furthermore, 0.4% COAC significantly enhanced the intestinal barrier function via increasing jejunal and ileal ocln transcription, promoting jejunal MUC-2 transcription at 42 days of age (P < 0.05), and decreasing jejunal TLR-2 and ileal TLR-15, iNOS compared with control group (P < 0.05). Whereas, no significant differences on the transcription of IL-1β in jejunum and ileum were observed among three treatments (P > 0.05). Overall, heat stress caused by high natural environment temperature may induce the damage to hepatic antioxidation and intestinal barrier.
Conclusion
Dietary inclusion of COAC can improve the tolerance of broilers to thermal environment through the modification of antioxidative parameters in liver and the mRNA expression of genes in intestinal barrier, resulting in an optimal inclusion level of 0.4%.
Keywords: Growth Performance, Compound Organic Acid Calcium, Antioxidation, Intestinal Barrier, Heat Stress, Broiler


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