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Asian-Australas J Anim Sci > Accepted Articles
DOI: https://doi.org/10.5713/ajas.18.0225    [Accepted] Published online July 1, 2019.
Expression of lipid metabolism genes provides new insights into intramuscular fat deposition in Laiwu pigs
Hui Wang1, Jin Wang1, Dan-dan Yang1, Zong-li Liu1, Yong-qing Zeng1,*, Wei Chen1,* 
Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, College of Animal Science and Technology, Shandong Agricultural University, Tai'an, Shandong 271000, China
Correspondence:  Yong-qing Zeng,Email: yqzeng@sdau.edu.cn
Wei Chen, Tel: +86-538-8242478, Fax: +86-538-8241419, Email: wchen@sdau.edu.cn
Received: 16 March 2018   • Revised: 23 July 2018   • Accepted: 11 June 2019
Abstract
Objective
The objective of this study was to measure the special expression pattern of lipid metabolism genes and investigate the molecular mechanisms underlying intramuscular fat (IMF) deposition in Longissimus dorsi muscle of Laiwu pigs. Method: Thirty-six pigs (Laiwu n =18; Duroc×Landrace×Yorkshire n = 18) were used for the measurement of the backfat thickness, marbling score, IMF content, and expression of lipid metabolism genes.
Results
Significant correlations were found between IMF content and the mRNA expression of lipid metabolism genes. Of the 14 fat deposition genes measured, FASN showed the strongest correlation (r = 0.75, p=0.001) with IMF content, and of the 6 fat removal genes, CPT1B exhibited the greatest negative correlation (r = −0.66, p=0.003) with IMF content in Laiwu pig. Multiple regression analysis showed that CPT1B, FASN, SLC27A1, and FABP3 contributed 38% of the prediction value for IMF content in Laiwu pigs. Of these four variables, CPT1B had the greatest contribution to IMF content (14%) followed by FASN (11%), SLC27A1 (9%) and FABP3 (4%).
Conclusion
Our results indicate that the combined effects of an upregulation in fat deposition genes and downregulation in fat removal genes promotes IMF deposition in Laiwu pigs.
Keywords: Gene Expression; Intramuscular Fat; Laiwu Pig; Lipid Metabolism; Longissimus dorsi Muscle
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