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Asian-Australas J Anim Sci > Accepted Articles
DOI: https://doi.org/10.5713/ajas.18.0624    [Accepted] Published online January 4, 2019.
Effect of reduced energy density of close-up diets on metabolites, lipolysis and gluconeogenesis in Holstein cows
Wenming Huang1,2  , Libin Wang1,2, Shengli Li2,*, Zhijun Cao2,*
1College of Animal Science, Southwest University, Chongqing 402460, China
2State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China
Correspondence:  Shengli Li,Email: lisheng0677@163.com
Zhijun Cao,Email: caozhijun@cau.edu.cn
Received: 21 August 2018   • Revised: 11 November 2018   • Accepted: 20 December 2018
Objective: An experiment was conducted to determine the effect of reduced energy density of close-up diets on metabolites, lipolysis and gluconeogenesis in cows during the transition period.


Thirty-nine Holstein dry cows were blocked and assigned randomly to three groups, fed a high energy density diet [HD, 1.62 Mcal of net energy for lactation (NEL)/kg dry matter (DM) ], a medium energy density diet (MD, 1.47 Mcal NEL/kg DM), or a low energy density diet (LD, 1.30 Mcal NEL/kg DM) prepartum; they were fed the same lactation diet to 28 days in milk (DIM). All the cows were housed in a free-stall barn and fed for ad libitum intake.


The reduced energy density diets decreased the blood insulin concentration and increased nonesterified fatty acids (NEFA) concentration in the prepartum period (p < 0.05). They also increased the concentrations of glucose, insulin and glucagon, and decreased the concentrations of NEFA and β-hydroxybutyrate during the first 2 weeks of lactation (p < 0.05). The plasma urea nitrogen concentration of both prepartum and postpartum was not affected by dietary energy density (p > 0.05). The dietary energy density had no effect on mRNA abundance of insulin receptors, leptin and peroxisome proliferator-activated receptor-γ in adipose tissue, and phosphoenolpyruvate carboxykinase, carnitine palmitoyltransferase-1 and peroxisome proliferator-activated receptor-α in liver during the transition period (p > 0.05). The HD cows had higher mRNA abundance of hormone-sensitive lipase at 3 DIM compared with the MD cows and LD cows (p = 0.001). The mRNA abundance of hepatic pyruvate carboxykinase at 3 DIM tended to be increased by the reduced energy density of the close-up diets (p = 0.08).
The reduced energy density diet prepartum was effective in controlling adipose tissue mobilization and improving the capacity of hepatic gluconeogenesis postpartum.
Keywords: Transition Cow; Dietary Energy Density; Lipolysis; Gluconeogenesis; Blood Metabolites

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