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Asian-Australas J Anim Sci > Accepted Articles
DOI: https://doi.org/10.5713/ajas.18.0588    [Accepted] Published online January 2, 2019.
In ovo feeding of creatine pyruvate alters energy metabolism in muscle of embryos and post-hatch broilers
Tong Yang1,2, Minmeng Zhao1,2, Jiaolong Li1,2, Lin Zhang1,2, Yun Jiang3, Guanghong Zhou1,2, Feng Gao1,2,*
1College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China
2Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control. Nanjing Agri-cultural University, Nanjing 210095, China
3Ginling College, Nanjing Normal University, Nanjing 210097, China
Correspondence:  Feng Gao, Tel: +86-025-84399007, Fax: +86-025-84395314, Email: gaofeng0629@sina.com
Received: 6 August 2018   • Revised: 8 November 2018   • Accepted: 6 December 2018
Objective: This study was conducted to investigate the effects of in ovo feeding (IOF) of creatine pyruvate (CrPyr) on the energy metabolism in thigh muscle of embryos and neonatal broilers.


A total of 960 eggs were randomly assigned to three treatments: 1) non-injected control group, 2) saline group injected with 0.6 mL of physiological saline (0.75%), and 3) CrPyr group injected with 0.6 mL of physiological saline (0.75%) containing 12 mg CrPyr/egg on 17.5 d of incubation. After hatching, 120 male chicks (close to the average body weight of the pooled group) in each group were randomly assigned to eight replications. The feeding experiment lasted 7 days.


The results showed that IOF of CrPyr increased glucose concentrations in the thigh muscle of broilers on 2 d after injection (P < 0.05). Compared with the control and saline groups, the concentration of creatine in CrPyr group was increased on 2 d after injection and the day of hatch (P < 0.05). Moreover, IOF of CrPyr increased the creatine kinase (CK) activity at hatch and increased the activities of hexokinase (HK) and pyruvate kinase (PK) on 2 d after injection and the day of hatch (P < 0.05). Chicks in CrPyr group showed higher mRNA expressions of GLUT3 and GLUT8 on the day of hatch (P < 0.05).
These results demonstrated that IOF of CrPyr was beneficial to enhance muscle energy reserves of em-bryos and hatchlings.
Keywords: Broilers; In ovo Injection; Creatine Pyruvate; Muscle; Energy Reserves
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