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Asian-Australas J Anim Sci > Accepted
doi: https://doi.org/10.5713/ajas.16.0414    [Accepted]
Association of a missense mutation in the positional candidate gene GRIP1 with backfat thickness traits in pigs
Jae-Bong Lee, Hee-Bok Park1, Chae-Kyoung Yoo2, Hee-Sung Kim3, In-Cheol Cho1, Hyun Tae Lim2,3,*
Korea Zoonosis Research Institute (KoZRI), Chonbuk National University, Iksan, Korea
1Subtropical Livestock Research Institute, National Institute of Animal Science, Jeju, Korea
2Institute of Agriculture and Life Science, Gyeongsang National University, Jinju, Korea
3Division of Applied Life Science (BK21 plus), Gyeongsang National University, Jinju, Korea
* Corresponding Author: Hyun Tae Lim ,Tel: 82557721945, Fax: 82557721949, Email: s_htim@gnu.ac.kr
Received: May 30, 2016;  Revised: October 10, 2016.  Accepted: December 16, 2016.  Published online December 27, 2016.

Previously, we reported quantitative trait loci (QTLs) affecting backfat thickness (BFT) traits on pig chromosome 5 (SW1482–SW963) in an F2 intercross population between Landrace and Korean native pigs. The aim of this study was to evaluate glutamate receptor-interacting protein 1 (GRIP1) as a positional candidate gene underlying the QTL affecting BFT traits.
Genotype and phenotype analyses were performed using the 1,105 F2 progeny. A mixed-effect linear model was used to access association between these SNP markers and the BFT traits in the F2 intercross population.
Highly significant associations of two informative SNPs [c.2442 T>C, c.3316 C>G (R1106G)] in GRIP1 with BFT traits were detected. In addition, the two SNPs were used to construct haplotypes that were also highly associated with the BFT traits.
The SNPs and haplotypes of the GRIP1 gene determined in this study can contribute to understand the genetic structure of BFT traits in pigs.
Keywords: GRIP1; backfat; QTL; Landrace; Korean native pigs
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