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Asian-Australas J Anim Sci > Volume 23(3); 2010 > Article
Poultry and Laboratory Animal Nutrition
Asian-Australasian Journal of Animal Sciences 2010;23(3): 379-384.
DOI: https://doi.org/10.5713/ajas.2010.70653    Published online February 22, 2010.
Effects of Dietary Betaine on the Secretion of Insulin-like Growth Factor-I and Insulin-like Growth Factor Binding Protein-1 and -3 in Laying Hens
H. S. Choe, H. L. Li, J. H. Park, C. W. Kang, K. S. Ryu
Abstract
The principal objective of this experiment was to determine the effects of dietary betaine on IGF-I, IGFBP-3 and IGFBP-1 secretion and IGF-I mRNA gene expression in the serum and liver of laying hens. A total of 72 ISA-Brown laying hens were fed with four different levels of betaine (0, 300, 600, 1,200 ppm) based on a corn-soybean meal diet containing 2,800 kcal/kg of metabolizable energy (ME) and 16% crude protein (CP) for four weeks. The results indicated significantly higher serum and liver IGF-I concentrations in the laying hens fed with 600 and 1,200 ppm betaine (p<0.05) compared to controls. IGF-I gene expression in liver showed a statistically correlated increase in 600 and 1,200 ppm betaine-fed groups as compared to the controls (p<0.05). Serum IGFBP-3 concentrations were elevated significantly in the groups fed 600 ppm of betaine. However, the secretion of IGFBP-1 in the liver of laying hens fed on 600 and 1,200 ppm of betaine was significantly lower than in the controls (p<0.05). The results of this experiment showed that dietary betaine supplementation plays a pivotal role in changes of the IGFs system in laying hens.
Keywords: Betaine; Laying Hens; Insulin-like Growth Factor-I; Insulin-like Growth Factor Binding Protein; IGF-I mRNA Gene Expression


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