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Asian-Australas J Anim Sci > Volume 22(10); 2009 > Article
Review Paper
Asian-Australasian Journal of Animal Sciences 2009;22(10): 1447-1460.
DOI: https://doi.org/10.5713/ajas.2009.90042    Published online August 26, 2009.
Myogenic Satellite Cells and Its Application in Animals - A Review
N. K. Singh, H. J. Lee, D. K. Jeong, H. S. Arun, L. Sharma, I. H. Hwang
Abstract
Myogenic satellite cells have been isolated and identified by several recently elucidated molecular markers. Furthermore, knowledge about the precise function of these markers has provided insight into the early and terminal events of satellite cells during proliferation, differentiation, transdifferentiation, specification and activation. Recently, quiescent myogenic satellite cells have been associated with possession of Pax 3 and 7 that represent pluripotent stem cells capable of differentiating into other lineages. However, the mechanism by which myogenic satellite cells attain pluripotent potential remain elusive. Later, transdifferentiating ability of these cells to another lineage in the absence or presence of certain growth factor/ or agents has revolutionized the scope of these pluripotent myogenic satellite cells for manipulation of animal production (in terms of quality and quantity of muscle protein) and health (in terms of repair of skeletal muscle, cartilage or bone).
Keywords: Satellite Cells; Myogenesis; Plasticity; Transdifferentiation; Adipogenesis; Review


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