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Review Paper
Asian-Australasian Journal of Animal Sciences 2008;21(5): 754-768.
DOI: https://doi.org/10.5713/ajas.2008.r.05    Published online May 6, 2008.
Growth Hormone Signaling in the Regulation of Acid Labile Subunit
Jin Wook Kim*, Yves R. Boisclair
Correspondence:  Jin Wook Kim,
Abstract
The past decades have seen enormous advances in our understanding of how GH acts. GH is a pituitary-derived polypeptide hormone that has diverse physiological effects including the regulation of bone growth, carbohydrate and lipid metabolism. The effects of GH are mediated directly and indirectly through IGF-I. In addition, GH stimulates the hepatic production of ALS. In postnatal life, IGF-I and -II circulate as 150 kDa ternary complexes consisting of one molecule each of IGFBP-3 or IGFBP-5, IGF-I or IGF-II and ALS. It is now known that ALS increases significantly the half-lives of the IGFs, IGFBP-3 and -5, and therefore is responsible for maintaining a circulating reservoir for each of these proteins.
Keywords: Growth Hormone; Signaling; Acid Labile Subunit
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