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Animal Breeding and Genetics
Asian-Australasian Journal of Animal Sciences 2008;21(3): 309-313.
DOI: https://doi.org/10.5713/ajas.2008.60476    Published online March 4, 2008.
Association Analysis between Insulin-like Growth Factor Binding Protein 3 (IGFBP3) Polymorphisms and Carcass Traits in Cattle
Hyun Sub Cheong, Du-Hak Yoon, Lyoung Hyo Kim, Byung Lae Park, Hye Won Lee, Sohg Namgoong, Eun Mi Kim, Eui Ryong Chung, Il-Cheong Cheong, Hyoung Doo Shin*
Correspondence:  Hyoung Doo Shin,
The insulin-like growth factor binding protein 3 (IGFBP3) has been investigated as a candidate gene for growth promoting effects in beef cattle and a modulator of IGF bioactivity. Previously, we have reported twenty two sequence variants discovered in Korean native cattle (Hanwoo). In this study, we examined the association between gene-specific polymorphisms of IGFBP3 and cold carcass weight (CW) and marbling score (MS) among Korean native cattle. Among twenty two polymorphisms, four common polymorphic sites (-854G>C, -100G>A, +421G>T and +3863C>A) were genotyped in our beef cattle (n = 437). Statistical analysis revealed that one common polymorphism in the promoter region (-854G>C) showed putative associations with MS (p = 0.03). IGFBP3 variation/haplotype information analyzed in this study will provide valuable information into strategies for the production of a commercial line of beef cattle.
Keywords: IGFBP3; Cold Carcass Weight; Marbling Score; Polymorphism

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