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Asian-Australas J Anim Sci > Volume 20(10); 2007 > Article
Animal Reproduction and Physiology
Asian-Australasian Journal of Animal Sciences 2007;20(10): 1503-1509.
DOI: https://doi.org/10.5713/ajas.2007.1503    Published online August 30, 2007.
Effects of Endothelin A Receptor Antagonist BQ123 on Femoral Artery Pressure and Pulmonary Artery Pressure in Broiler Chickens
Huiyu Wang, Jian Qiao, Mingyu Gao, Ying Yang, Kai Li, Jianlin Wang, Yong Tian, Tong Xu
Abstract
Endothelin-1 (ET-1) is an important factor in regulation of cardiovascular tone in humans and mammals, but the biological function of ET-1 in the avian vascular system has not been determined. The purpose of this study was to characterize the role of endogenous ET-1 in the vascular system of poultry by investigating the effect of endothelin A receptor (ETAR) antagonist BQ123 on the femoral artery pressure (FAP) and the pulmonary artery pressure (PAP) in broiler chickens. First, we found that plasma and lung homogenate ET-1 levels were both increased with age over the seven weeks life cyccle of broiler chickens. Second, 60 min after intravenous injection, BQ123 (0.4 ??g kg-1 and 2.0 ??g kg-1, respectively) induced a significant reduction in FAP and PAP (p<0.05). Third, chronic infusion of BQ123 (2.0 ??g kg-1 each time, two times a day) into abdominal cavities led to significant decrease in systolic pressure of the femoral (p<0.05) and pulmonary arteries (p<0.01) in broiler chickens at 7 and 14 days after treatment. Taken together, the ETAR antagonist BQ123 lead to a significant reduction of FAP and PAP, which suggests that endogenous ET-1 may be involved in the maintenance and regulation of systemic and pulmonary pressure in broiler chickens.
Keywords: BQ123; Endothelin-1; Femoral Artery Pressure; Pulmonary Artery Pressure; Broiler Chickens


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