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Asian-Australasian Journal of Animal Sciences 2006;19(2): 297-304.
DOI: https://doi.org/10.5713/ajas.2006.297    Published online December 7, 2005.
Effect of IGF-I Rich Fraction from Bovine Colostral Whey on Murine Immunity
Kyung-A Hwang, Woel-Kyu Ha, Hee-Jin Yang, Soo-Won Lee
Abstract
Insulin-like growth factor-I (IGF-I) rich fraction, collected components between 1 kDa and 30 kDa, was fractionated from bovine colostral whey using an ultrafiltration membrane. IGF-I was confirmed in the collected IGF-I rich fraction by both SDSPAGE and Western blotting. The concentration of IGF-I in the IGF-I rich fraction was 10 ng/mg protein. One hundred microliters of the reconstituted IGF-I rich fraction was intraperitoneally injected into ICR male mice for 2 weeks at 24 h intervals. The functions of peritoneal macrophages, including phagocytosis, interleukin (IL)-6 and tumor necrosis factor (TNF)-慣 production, and nitric oxide and hydrogen peroxide production, were enhanced significantly by the administration of the IGF-I rich fraction in a dose-dependent manner (p<0.01). The proliferation of Concanavalin (Con) A-stimulated and Lipopolysaccharide (LPS)-stimulated splenocytes was also determined to have been enhanced significantly by the administration of the IGF-I rich fraction in a dose-dependent manner (p<0.01). Our results indicate that the administration of IGF-I rich fraction obtained from bovine colostral whey enhances both innate and acquired immunity for ICR male mice.
Keywords: IGF-I; Colostrum; Macrophage; Splenocyte; Immunity
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