Go to Top Go to Bottom
Review Paper
Asian-Australasian Journal of Animal Sciences 2005;18(10): 1505-1512.
DOI: https://doi.org/10.5713/ajas.2005.1505    Published online December 2, 2005.
Biochemical and Molecular Insights into Bile Salt Hydrolase in the Gastrointestinal Microflora - A Review -
Geun-Bae Kim, Byong H. Lee
Abstract
Bile salt deconjugation is the most biologically significant reaction among the bacterial alterations of bile acids in the gastrointestinal tract of human and animal. The responsible enzyme, bile salt hydrolase (BSH), catalyzes the hydrolysis of glycineand/ or taurine-conjugated bile salts into amino acid residues and deconjugated bile acids. Herein we review current knowledge on the distribution of BSH activity among various microorganisms with respect to their biochemical and molecular characteristics. The proposed physiological impact of BSH activity on the host animal as well as on the BSH-producing bacterial cells is discussed. BSH activity of the probiotic strains is examined on the basis of BSH hypothesis, which was proposed to explain cholesterol-lowering effects of probiotics. Finally, the potential applications of BSH research are briefly discussed.
Keywords: Bile Salt Hydrolase (BSH); Gut Microbes; Probiotics; Cholesterol Lowering; Genetic Marker


Editorial Office
Asian-Australasian Association of Animal Production Societies(AAAP)
Room 708 Sammo Sporex, 23, Sillim-ro 59-gil, Gwanak-gu, Seoul 08776, Korea   
TEL : +82-2-888-6558    FAX : +82-2-888-6559   
E-mail : jongkha@hotmail.com               

Copyright © 2020 by Asian-Australasian Journal of Animal Sciences. All rights reserved.

Close layer
prev next