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Asian-Australas J Anim Sci > Volume 18(9); 2005 > Article
Swine Nutrition and Feed Technology
Asian-Australasian Journal of Animal Sciences 2005;18(9): 1320-1325.
DOI: https://doi.org/10.5713/ajas.2005.1320    Published online December 1, 2005.
Effects of Olaquindox and Cyadox on Immunity of Piglets Orally Inoculated with Escherichia coli
Mingxing Ding, Zonghui Yuan, Yulian Wang, Huiling Zhu, Shengxian Fan
Abstract
A 2횞3 factorial arrangement of treatments was used to determine the effects of olaquindox and cyadox on immune response of Landrace횞Large-White geld piglets that had been orally given 1010 CFU of Escherichia coli (E. coli, O139:K88). Factors included (1) E. coli inoculation or control, and (2) no antimicrobials, 100 mg/kg olaquindox and 100 mg/kg cyadox in the basal diet respectively. E. coli inoculums were orally administered 7 days after the diets were supplemented with olaquindox and cyadox. The effects of the two antimicrobials were assessed in terms of: (1) average daily gain (ADG), (2) systemic immune response (the number of white blood cells and lymphocytes, leukocyte bactericidal capacity, lymphocyte proliferation response to PHA, immunoglobulin concentrations, and total serous hemolytic complement activity), and (3) intestinal mucosal immunity including the number of intraepithelial lymphocytes (IELs) and immunoglobulin A secreting cells (ASCs) in the intestinal lamina propria. E. coli inoculation reduced ADG (p<0.05) during the period of d 0 to d 14 after the challenge while the antimicrobial supplementations improved ADG (p<0.01) during the experiment. ADG in cyadox-supplemented pigs was higher (p<0.05) than that in olaquindox-supplemented pigs. The antimicrobials decreased IEL and ASC counts in the jejunum and ileum (p<0.01) while E. coli inoculation caused them to increase (p<0.01). Jejunal ASCs in the cyadox-supplemented pigs were lower (p<0.05) than those in the olaquindox-supplemented. E. coli elicited increase (p<0.05) in white blood cell counts, leukocyte bactericidal capacity, lymphocyte proliferation rate, serous IgA concentrations, and serous hemolytic complement activity. The antimicrobials decreased the measured systemic immune parameters, but not significantly (p>0.05). The data suggest that olaquindox and cyadox suppress E. coli-induced immune activation, especially intestinal mucosal immune activation, which may be involved in the observed growth promotion.
Keywords: Quinoxalines; Antimicrobials; Immunity; Growth; Pigs


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