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Swine Nutrition and Feed Technology
Asian-Australasian Journal of Animal Sciences 2001;14(4): 535-539.
DOI: https://doi.org/10.5713/ajas.2001.535    Published online April 1, 2001.
Effect of Fermented Chub Mackerel Extract on Lipid Metabolism of Rats Fed Diets without Cholesterol
U. Santoso, S. Ishikawa, K. Tanaka
Abstract
The present study was conducted to evaluate the effect of fermented chub mackerel extract (FCME) on lipid metabolism in rats fed diets without cholesterol. Four week-old male rats were divided into three groups of 10 rats with 0, 1% or 2% FCME supplementation to the diets. Purified diets were used in the present study. Feed and water were fed ad libitum. FCME supplementation had no effect on the activities of acetyl-CoA carboxylase, fatty acid synthetase, and the content of free cholesterol, triglyceride and phospholipid in the liver (p>0.05). 1% FCME supplementation significantly increased serum triglyceride (p<0.05) and hepatic 3-hydroxy-3-methylglutaryl-CoA reductase activity (p<0.05) with no effect on serum total cholesterol, free cholesterol and phospholipid concentration. FCME supplementation significantly reduced serum LDL+VLDL-cholesterol (p<0.01) and atherogenic index (p<0.01) with no effect on HDL-cholesterol. The current study showed that FCME inclusion might reduce the risk of atherosclerosis in rats fed diet without cholesterol.
Keywords: Fermented Chub; Mackerel Extract; Lipid Metabolism; Rats


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