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Ruminant Nutrition and Forage Utilization
Asian-Australasian Journal of Animal Sciences 1996;9(4): 449-454.
DOI: https://doi.org/10.5713/ajas.1996.449    Published online August 1, 1996.
Cytogenetic effects of organophosphate pesticides on goat lymphocuytes in culture
S. C. Gupta, R. Sahal, N. Gupta
Abstract
Cytogenetic effects of malathion and parathion, the organophosphorus pesticides were studied on goat lymphocytes in culture. The mitotic indices(% of blast cells + cells at metaphaed) of goat lymphocytes showed corresponding decrease with the increase in dose of pesticides. Malathion had significant effect only at 150 關g/ml or igher dosages while, parathion caused antimitotic effects even at the lowest dose(5 關g/ml) tested. The clastogenic effects of malathion were significant(p<.01). The frequency of metaphase plates with chromosomal abnormalities were highest(22.0%) at 200 關g/ml. The incidences of chromosomal abnormalities were significant(p<.05) in parathion treated series even at 5 關g/ml dose level. At 10 關g/ml or higher dose levels the difference between treatment groups and controls were more pronounced(p<.01). Various types of chromosomal abnormalities were encountered in goat lymphocytes treated by malathion and parathion. However, the incidence of gaps, breaks, acentric fragments, dicentric chromosomes were higher than other types of structural and numerical abnormalities.
Keywords: Goat; Organophosphorous Pesticides; Mitotic Index; Chromosomal Aberrations


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