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Asian-Australas J Anim Sci > Volume 7(4); 1994 > Article
Review Paper
Asian-Australasian Journal of Animal Sciences 1994;7(4): 459-466.
DOI: https://doi.org/10.5713/ajas.1994.459    Published online December 1, 1994.
Primordial germ cells in aves - Review -
J. Y. Han, D. S. Seo, R. N. Shoffner
Abstract
Primordial germ cells (PGCs) in aves are the progenitor cells for the gametes. These cells first appear in the epiblast (Eyal-Giladi et al.. 1981). Then translocate and concentrate to endoderm of germinal crescent area in the junction of the area opaca and area pellucida lateral to the primitive streak in stage 4 through 7. They separate from the endoderm, temporarily circulate via the blood vascular system, leave the blood vessels, and finally settle down in the gonadal anlagen at stage 20-24 where they rapidly proliferate to form germ cells. Recently, several attempts have been made to introduce foreign gene into the avian genome to form a transgenic chicken. The stem cells most readily available as vehicles for genetic manipulation of germiline in avian species are the PGCs. PGCs have recently been manipulated genetically and used successfully as a vector for gene transfer.
Keywords: Primordial Germ Cell (PGC); Cerminal Crescent; Germline Transgenic Chicken


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