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Animal Reproduction and Physiology
Asian-Australasian Journal of Animal Sciences 1991;4(1): 15-19.
DOI: https://doi.org/10.5713/ajas.1991.15    Published online March 1, 1991.
Restriction by motherworst (Leonurus sibiricus L) of lactation suppressed by pregnancy-Dependent Mammary Tumors in GR/A Mice
H. Nagasawa, M. Suzuki, H. Inatomi, A. Hibino, Y. Yamamuro, N. Sensui
Abstract
As a possible step to evaluate in the mammary gland the role of motherwort (Leonurus sibiricus L), a representative medicinal plant used traditionally for the therapy of gynecologic diseases, the effects of the agent on lactation which was suppressed by preganacy-dependent mammary tumors (PDMT) were studied in GR/A mice. Beginning the day of placing with males at 45-50 days of age, female mice were given 60% methanol-extract of the aerial part of motherwort as drinking water at the concentration of 0.5% throughout the experiment. Mice developing PDMT during pregnancy [PDMT(+)] and given motherwort were similar to mice developing no PDMT [PDMT(_)] with or without motherwort treatment and were significantly higher than PDMT(+) mice given tap water in litter growth and mammary RNA/DMA ratio on day 12 of the 2nd lactation. Mammary DNA and RNA contents were also elevated by motherwort in PDMT(+) mice. The results suggest that motherwort can ameliorate lactation suppressed by PDMT through its stimulation of both growth and function of the mammary glands.
Keywords: GR/A; Lactation; Motherwort; Mice; Pregnancy-Dependent Mammary Tumors
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