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Animal Reproduction and Physiology
Asian-Australasian Journal of Animal Sciences 1989;2(1): 23-26.
DOI: https://doi.org/10.5713/ajas.1989.23    Published online March 1, 1989.
Effects of chronic ingestion of anthranilic acid on lactation in mice
H. Nagasawa, M. Suzuki, N. Sakagami, H. Inatomi, K. Yamamoto
Abstract
Treatment of mice with 0.04% anthranilic acid (AnA) as drinking water resulted in an apparent stimulation of pup`s growth and food intake of mothers in their first lactations associated with an increased rearing rate and no alteration in plasma prolactin level. AnA showed no significant effects on the day of vaginal opening, the pattern of estrous cycles, plasma growth hormone level and endocrine organ weights of the female and male offspring. The growth of male offspring was significantly retarded by AnA, however, their reproductivity was quite normal. The results indicate the AnA can simulate lactation of mice through little modulation of endocrine systems.
Keywords: Anthranilic Acid; Body Growth; Food Intake; Lactation; Mouse


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