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Asian-Australas J Anim Sci > Volume 1(3); 1988 > Article
Animal Reproduction and Physiology
Asian-Australasian Journal of Animal Sciences 1988;1(3): 139-142.
DOI: https://doi.org/10.5713/ajas.1988.139    Published online September 1, 1988.
Effects of chronic ingestion of anthranilic acid on mammary gland growth in SHN Mice
H. Nagasawa, R. Konishi, N. Sakagami, H. Inatomi
Abstract
Effects of acid on normal mammary gland growth were examined in SHN/Mei female virgin mice. Anthranilic acid was given to the experimental groups as drinking water at the concentrations of 0.01, 0.02 or 0.04% for 21 days beginning 2-3 months of age. The control group received tap water only. RNA content and RNA/DNA ratio in mammary glands were significantly higher in mice given 0.04% anthranilic acid than in the control, while not mammary DNA content. The results indicate that chronic ingestion of anthranilic acid can induce an enhancement of proliferation and differentiation of mammary cells.
Keywords: Anthranilic Acid; DNA; Mammary; Growth; Mice


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