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Asian-Australas J Anim Sci > Volume 30(8); 2017 > Article
Asian-Australasian Journal of Animal Sciences 2017;30(8): 1099-1104. doi: https://doi.org/10.5713/ajas.16.0708
Effect of alcohol dehydrogenase 1C (ADH1C) genotype on vitamin A restriction and marbling in Korean native steers
Dong Qiao Peng1,2, U Suk Jung1, Jae Sung Lee1, Won Seob Kim1,2, Yong Ho Jo1,2, Min Jeong Kim1, Young Kun Oh3, Youl Chang Baek3, Seong Gu Hwang4, Hong Gu Lee1,2,*
1Department of Animal Science and Technology, College of Animal Bioscience and Technology, Konkuk University, Seoul 05029, Korea
2Team of An Educational Program for Specialists in Global Animal Science, Brain Korea 21 Plus Project, Konkuk University, Seoul 05029, Korea
3Animal Nutrition and Physiology team, Department of Animal Biotechnology and Environment, National Institute of Animal Science RDA, Jeonju 54875, Korea
4Department of Animal Life and Environment Science, Hankyong National University, Anseong 17579, Korea
* Corresponding Author: Hong Gu Lee ,Tel: +82-2-450-0523, Fax: +82-2-455-1044, Email: hglee66@konkuk.ac.kr
Received: September 19, 2016;  Revised: December 4, 2016.  Accepted: January 11, 2017.  Published online January 26, 2017.

ABSTRACT
Objective:
This work was to find the correlation of alcohol dehydrogenase 1C (ADH1C) genotype with vitamin A reduction and carcass traits during the vitamin A restriction period.
Method:
In study 1, 60 Korean native steers were fed a diet (890 IU/kg) with 8,000 IU and 0 IU of supplemental premix vitamin A/kg of dry matter (DM) for control and treatment group, respectively. The levels of serum vitamin A were analyzed through high preparative performance liquid chromatography, and the ADH1C genotype was analyzed based on polymerase chain reaction­restriction fragment length polymorphism (PCR­RFLP; 78.1% TT type, 21.9% TC type); however, CC type was not found. Then, the interaction between ADH1C and carcass traits on the vitamin A restriction was investigated in study 2. A total of 136 Korean native steers were fed a diet that included 930 IU/kg vitamin A of DM.
Results:
Serum vitamin A in treatment was reduced to 112.4 IU/dL in steers with TT type of ADH1C, while for steers with TC type the concentration of serum vitamin A was dropped to 79.5 IU/dL (p<0.1) in study 1. This showed that TC type had the potential to lower serum vitamin A concentration during vitamin A restriction compared to TT type. In study 2 we found that eye muscle area, marbling and carcass weight in Korean native steers with TC type were higher than in steers with TT type (p<0.05).
Conclusion:
The interaction between vitamin A restriction and TC type of ADH1C gene could have the potential of increasing the marbling in Korean native steers. These results indicated that steers with TC type of the ADH1C gene were more sensitive to the change of serum vitamin A than TT types. Furthermore, this finding has the potential to enable a higher marbling score under the condition of vitamin A restriction in Korean native steers.
Keywords: Vitamin A Restriction; Alcohol Dehydrogenase 1C (ADH1C); Polymerase Chain Reaction­Restriction Fragment Length Polymorphism (PCR­RFLP); Marbling; Korean Native Steers
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