| Home | Subscription | E-Submission | Sitemap | Contact Us |
top_img
17th_aaap_banner
Asian-Australas J Anim Sci > Volume 30(8); 2017 > Article
Asian-Australasian Journal of Animal Sciences 2017;30(8): 1066-1073. doi: https://doi.org/10.5713/ajas.16.0679
Genome-wide association study identifies 22 new loci for body dimension and body weight traits in a White Duroc×Erhualian F2 intercross population
Jiuxiu Ji1, Lisheng Zhou1, Yuanmei Guo1, Lusheng Huang1, Junwu Ma1,*
1National Key Laboratory for Pig Genetic Improvement and Production Technology, Jiangxi Agricultural University, Nanchang 330045, China
* Corresponding Author: Junwu Ma ,Tel: +86-791-83813080, Fax: +86-791-83813080, Email: ma_junwu@hotmail.com
Received: September 5, 2016;  Revised: November 9, 2016.  Accepted: January 8, 2017.  Published online January 13, 2017.

ABSTRACT
Objective:
Growth-related traits are important economic traits in the swine industry. However, the genetic mechanism of growth-related traits is little known. The aim of this study was to screen the candidate genes and molecular markers associated with body dimension and body weight traits in pigs.
Method:
A genome-wide association study (GWAS) on body dimension and body weight traits was performed in a White Duroc×Erhualian F2 intercross by the illumina PorcineSNP60K Beadchip. A mixed linear model was used to assess the association between single nucleotide polymorphisms (SNPs) and the phenotypes.
Results:
In total, 611 and 79 SNPs were identified significantly associated with body dimension traits and body weight respectively. All SNPs but 62 were located into 23 genomic regions (quantitative trait loci, QTLs) on 14 autosomal and X chromosomes in Sus scrofa Build 10.2 assembly. Out of the 23 QTLs with the suggestive significance level (5×10–4), three QTLs exceeded the genome-wide significance threshold (1.15×10–6). Except the one on Sus scrofa chromosome (SSC) 7 which was reported previously all the QTLs are novel. In addition, we identified 5 promising candidate genes, including cell division cycle 7 for abdominal circumference, pleiomorphic adenoma gene 1 and neuropeptides B/W receptor 1 for both body weight and cannon bone circumference on SSC4, phosphoenolpyruvate carboxykinase 1, and bone morphogenetic protein 7 for hip circumference on SSC17.
Conclusion:
The results have not only demonstrated a number of potential genes/loci associated with the growth-related traits in pigs, but also laid a foundation for studying the genes’ role and further identifying causative variants underlying these loci.
Keywords: Pig; Genome-wide Association Study (GWAS); Candidate Gene; Body Dimension; Body Weight
TOOLS
PDF Links  PDF Links
Full text via DOI  Full text via DOI
Download Citation  Download Citation
CrossRef TDM  CrossRef TDM
  E-Mail
Share:      
METRICS
0
Crossref
0
Scopus
788
View
9
Download
Editorial Office
Asian-Australasian Association of Animal Production Societies(AAAP)
Room 708 Sammo Sporex, 23, Sillim-ro 59-gil, Gwanak-gu, Seoul
08776, Korea   TEL : +82-2-888-6558    FAX : +82-2-888-6559   
E-mail : jongkha@hotmail.com
About |  Browse Articles |  Current Issue |  For Authors and Reviewers |  Privacy Policy
Copyright © 2014 by Asian-Australasian Journal of Animal Sciences. All rights reserved.                 powerd by m2community