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Asian-Australas J Anim Sci > Volume 30(8); 2017 > Article
Asian-Australasian Journal of Animal Sciences 2017;30(8): 1081-1085. doi: https://doi.org/10.5713/ajas.16.0414
Association of a missense mutation in the positional candidate gene glutamate receptor-interacting protein 1 with backfat thickness traits in pigs
Jae-Bong Lee1, Hee-Bok Park2, Chae-Kyoung Yoo3, Hee-Sung Kim4, In-Cheol Cho2, Hyun-Tae Lim3,4,*
1Korea Zoonosis Research Institute (KoZRI), Chonbuk National University, Iksan 54531, Korea
2Subtropical Livestock Research Institute, National Institute of Animal Science, Jeju 63242, Korea
3Institute of Agriculture and Life Science, Gyeongsang National University, Jinju 52828, Korea
4Division of Applied Life Science (BK21 plus), Gyeongsang National University, Jinju 52828, Korea
* Corresponding Author: Hyun-Tae Lim ,Tel: +82-55-772-1945, Fax: +82-55-772-1949, Email: s_htim@gnu.ac.kr
Received: May 30, 2016;  Revised: October 10, 2016.  Accepted: December 16, 2016.  Published online December 27, 2016.
Jae-Bong Lee and Hee-Bok Park contributed equally to this work.

Previously, we reported quantitative trait loci (QTLs) affecting backfat thickness (BFT) traits on pig chromosome 5 (SW1482–SW963) in an F2 intercross population between Landrace and Korean native pigs. The aim of this study was to evaluate glutamate receptor-interacting protein 1 (GRIP1) as a positional candidate gene underlying the QTL affecting BFT traits.
Genotype and phenotype analyses were performed using the 1,105 F2 progeny. A mixed-effect linear model was used to access association between these single nucleotide polymorphism (SNP) markers and the BFT traits in the F2 intercross population.
Highly significant associations of two informative SNPs (c.2442 T>C, c.3316 C>G [R1106G]) in GRIP1 with BFT traits were detected. In addition, the two SNPs were used to construct haplotypes that were also highly associated with the BFT traits.
The SNPs and haplotypes of the GRIP1 gene determined in this study can contribute to understand the genetic structure of BFT traits in pigs.
Keywords: Glutamate Receptor-interacting Protein 1 (GRIP1); Backfat; Quantitative Trait Loci (QTL); Landrace; Korean Native Pigs
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