AOAC. 2007. Official Methods of Analysis. 18th edAOAC international; Gaithersburg, MD, USA:
Calder PC, Yaqoob P. 1999. Glutamine and the immune system. Amino Acids 17:227–241.
Con J, Joseph B, Kulvatunyou N, Tang A, O’Keeffe T, Wynne JL, Friese RS, Rhee P, Latifi R. 2011. Evidence-based immune-modulating nutritional therapy in critically ill and injured patients. Eur Surg 43:13–18.
Doppenberg J, van der Aar PJ. 2010. Dynamics in Animal Nutrition. Wageingen Accademic Publishers; Wageingen, The Netherlands: p. 31–36.
Dugan MER, Knabe DA, Wu G. 1994. Glutamine and glucose metabolism in intraepithelial lymphocytes from pre- and post-weaning pigs. Comp Biochem Phys B Comp Biochem 109:675–681.
Evoy D, Lieberman MD, Fahey TJ, Daly JM. 1998. Immuninutrition: The role of arginine. Nutrition 14:611–617.
Figueroa JL, Lewis AJ, Miller PS, Fischer RL, Gómez RS, Diedrichsen RM. 2002. Nitrogen metabolism and growth performance of gilts fed standard maize-soybean meal diets or low-crude protein, amino acid supplemented diets. J Anim Sci 80:2911–2919.
Guay F, Donovan SM, Trottier NL. 2006. Biochemical and morphological developments are practically impaired in intestinal mucosa from growing pigs fed reduced-protein diets supplemented with crystalline amino acids. J Anim Sci 84:1749–1760.
Guy-Grand D, DiSanto JP, Henchoz P, Malassis-Séris M, Vassalli P. 1998. Small bowel enteropathy: role of interepithelial lymphocytes and of cytokines (IL-12, INF-γ, TNF) in the induction of epithelial cell death and renewal. Eur J Immunol 28:730–744.
Heo JM, Kim JC, Hansen CF, Mullan BP, Hanpson DJ, Pluske JR. 2008. Effects of feeding low protein diets to piglets on plasma urea nitrogen, faecal ammonia nitrogen, the incidence of diarrhoea and performance after weaning. Arch Anim Nutr 62:343–358.
Htoo JK, Araiza BA, Sauer WC, Rademacher M, Zhang Y, Cervantes M, Aijlstra RT. 2007. Effect of dietary protein content on ileal amino acid digestibility, growth performance, and formation of microbial metabolites in ileal and cecal digest of early-weaned pigs. J Anim Sci 85:3303–3312.
Kerr BJ. 2003. Dietary manipulation to reduce environmental impact. p. 139–158. In : 9th International Symposium on Digestive Physiology in Pigs; May 14–17, 2003; Banff, Alberta, Canada.
Lallès JP, Bosi P, Smidt H, Stokes CR. 2007. Nutritional management of gut health in pigs around weaning. Proc Nutr Soc 66:260–268.
Li P, Yin Y, Li D, Kim SW, Wu G. 2007. Amino acids and immune function. Br J Nutr 98:237–252.
Lordelo MM, Gaspar AM, Le Bellego L, Freire JPB. 2008. Isoleucine and valine supplementation of a low-protein corn-wheat-soybean meal-based diet for piglets: growth performance and nitrogen balance. J Anim Sci 86:2936–2941.
Lundqvist C, Baranov V, Hammarstrōm S, Athlin L, Hammarstrōm ML. 1995. Intra-epithelial lymphocytes. Evidence for regional specialization and extrathymic T cell maturation in the human gut epithelium. Int Immunol 7:1473–1487.
Mao X, Zeng X, Qiao S, Wu G, Li D. 2011. Specific roles of threonine in intestinal mucosal integrity and barrier function. Front Biosci E3:1192–1200.
McCracken BA, Gaskins HR, Ruwe-Kaiser PJ, Klasing KC, Jewell DE. 1995. Diet-dependent and diet-independent metabolic responses underlie growth stasis of pigs at weaning. J Nutr 125:2838–2845.
McGuckin AM, Eri R, Simms LA, Florin THJ, Radford-Smith G. 2009. Intestinal barrier dysfunction in inflammatory bowel diseases. Inflamm Bowel Dis 15:100–113.
Miller BG, Jamies PS, Smith MW, Bourne FJ. 1986. Effect of weaning on the capacity of pig intestinal villi to digest and absorb nutrients. J Agric Sci Camb 107:579–589.
Moore S. 1963. On the determination of cystine as cysteic acid. J Biol Chem 238:235–237.
Nabuurs MJ, Hoogendoorn A, Molen EJV, Van Osta AL. 1993. Villous height and crypt depth in weaned and unweaned pigs, reared under various circumstances in the Netherlands. Res Vet Sci 55:78–84.
NRC. 1998. Nutrient Requirements of Swine. 10th EditionNational Academy Press; Washington DC, USA:
NRC. 2012. Nutrient Requirements of Swine. 11th EditionNational Academy Press; Washington DC, USA:
Nofrarías M, Manzanilla EG, Pujols J, Gibert X, Majó N, Segalés J, Gasa J. 2006. Effects of spray- dried porcine plasma and plant exreacts on intestinal morphology and on leukocyte cell subsets of weaned pigs. J Anim Sci 84:2735–2742.
Nyachoti CM, Omoghenigun FO, Rademacher M, Blank G. 2006. Performance responses and indicators of gastrointestinal health in early-weaned pigs fed low-protein amino acids-supplemented diets. J Anim Sci 84:125–134.
Oswald IP. 2006. Role of intestinal epithelial cells in the innate immune defence of the pig intestine. Vet Res 37:359–368.
Wijtten JAP, van der Meulen J, Verstegen MWA. 2011. Intestinal barrier function and absorption in pigs after weaning: A review. Br J Nutr 105:967–981.
Pié S, Lallè JP, Blazy F, Laffitte J, Sève B, Oswald IP. 2004. Weaning is associated with an upregulation of expression of inflammatory cytokines in the intestine of piglets. J Nutr 124:641–647.
Pluske JR, Thompson MJ, Atwood CS, Bird PH, Williams IH, Hartmann PE. 1996. Maintenance of villous height and crypt depth, and enhancement of disaccharide digestion and monosaccharide absorption, in piglets fed on cows’ whole milk after weaning. Br J Nutr 76:409–422.
Pomorska-Mól M, Markowska-Daniel I. 2011. Porcine cathelicidins and defensins. Med Weter 67:20–24.
Rose N, Larour G, Le Digyerher G, Everno E, Jolly JP, Blanchard P, Oger A, Le Dimna M, Jestin A, Madec F. 2003. Risk factors for porcine post-weaning multisystemic wasting syndrome (PMWS) in 149 French farrow-to-finish herds. Prev Vet Med 61:209–225.
Simone DR, Vissicchio F, Mingarelli C, Nuccio CD, Visentin S, Ajmone-Cat MA, Minghetti L. 2013. Branched-chain amino acids influence the immune properties of microglial cells and their responsiveness to pro-inflammatory signals. Biochim Biophys Acta Mol Basis Dis 1832. 650–659.
Stoll B, Henry J, Reeds PJ, Yu H, Jahoor F, Burrin DG. 1998. Catabolism dominates the first-pass intestinal metabolism of dietary essential amino acids in milk protein-fed piglets. J Nutr 128:606–614.
Tan B, Li XG, Kong X, Huang R, Ruan Z, Yao K, Deng Z, Xie M, Shinzato I, Yin Y, Wu G. 2009. Dietary L-arginine supplementation enhances the immune status in early-weaned pglets. Amino Acids 37:323–331.
Wang JJ, Chen L, Li P, Li X, Zhou H, Wang F, Li D, Yin Y, Wu G. 2008. Gene expression is altered in piglet small intestine by weaning and dietary glutamine supplementation. J Nutr 138:1025–1032.
Wells JM, Loonen LMP, Karczewski JM. 2010. The role of innate signalling in the homeostasis of tolerance and immunity in the intestine. Int J Med Microbiol 300:41–48.
Wu G. 1998. Intestinal mucosal amino acid catabolism. J Nutr 128:1249–1252.
Wu G. 2009. Amino acids: Metabolism, functions, and nutrition. Amino Acids 37:1–17.
Yoneda J, Andou A, Takehana K. 2009. Regulatory roles of amino acids in immune response. Curr Rheumatol Rev 5:252–258.
Yue LY, Qiao SY. 2007. Effects of low-protein diets supplemented with crystalline amino acids on performance and intestinal development in piglets over the first 2 weeks after weaning. Livest Sci 115:144–152.
Zhang F, Zeng X, Yang F, Huang Z, Liu H, Ma X, Qiao S. 2013. Dietary N-carbamylglutamate supplementation boosts intestinal mucosal immunity in
Escherichia coli challenged piglets. Plos One 8:6e66280
Zhu HL, Liu YL, Xie XL, Huang JJ, Hou YQ. 2013. Effect of L-arginine on intestinal mucosal immune barrier function in weaned pigs after
Escherichia coli LPS challenge. Innate Immun 19:242–252.
Zijlstra RT, Odle J, Hall WF, Petschow BW, Gelbery HB, Litov RE. 1994. Effect of orally administered epidermal growth factor on intestinal recovery of neonatal pigs infected with rotavirus. J Pediatr Gastroenterol Nutr 19:382–390.