Abasht B, Kaiser MG, Lamont SJ. 2008. Toll-like receptor gene expression in cecum and spleen of advanced intercross line chicks infected with
Salmonella enterica serovar Enteritidis. Vet Immunol Immunopathol 123:314–323.
Akira S, Takeda K, Kaisho T. 2001. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol 2:675–680.
Alam SN, Yammine H, Moaven O, Ahmed R, Moss AK, Biswas B, Muhammad N, Biswas R, Raychowdhury A, Kaliannan K, Ghosh S, Ray M, Hamarneh SR, Barua S, Malo NS, Bhan AK, Malo MS, Hodin RA. 2014. Intestinal alkaline phosphatase prevents antibiotic-induced susceptibility to enteric pathogens. Ann Surg 259:715–722.
Artis D. 2008. Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut. Nat Rev Immunol 8:411–420.
Bederska-Łojewska D, Pieszka M. 2011. Modulating gastrointestinal microflora of pigs through nutrition using feed additives. Ann Anim Sci 11:333–355.
Bentala H, Verweij WR, Huizinga-Van der Vlag A, van Loenen-Weemaes AM, Meijer DK, Poelstra K. 2002. Removal of phosphate from lipid A as a strategy to detoxify lipopolysaccharide. Shock 18:561–566.
Beumer C, Wulferink M, Raaben W, Fiechter D, Brands R, Seinen W. 2003. Calf intestinal alkaline phosphatase, a novel therapeutic drug for lipopolysaccharide (LPS)-mediated diseases, attenuates LPS toxicity in mice and piglets. J Pharmacol Exp Ther 307:737–744.
Beutler B, Rietschel ET. 2003. Innate immune sensing and its roots: the story of endotoxin. Nat Rev Immunol 3:169–176.
Bol-Schoenmakers M, Fiechter D, Raaben W, Hassing I, Bleumink R, Kruijswijk D, Maijoor K, Tersteeg-Zijderveld M, Brands R, Pieters R. 2010. Intestinal alkaline phosphatase contributes to the reduction of severe intestinal epithelial damage. Eur J Pharmacol 633:71–77.
Brun LR, Brance ML, Lombarte M, Lupo M, Di Loreto VE, Rigalli A. 2014. Regulation of intestinal calcium absorption by luminal calcium content: role of intestinal alkaline phosphatase. Mol Nutr Food Res 58:1546–1551.
Burkey TE, Skjolaas KA, Minton JE. 2009. Board-invited review: porcine mucosal immunity of the gastrointestinal tract. J Anim Sci 87:1493–1501.
Chen KT, Malo MS, Moss AK, Zeller S, Johnson P, Ebrahimi F, Mostafa G, Alam SN, Ramasamy S, Warren HS, Hohmann EL, Hodin RA. 2010. Identification of specific targets for the gut mucosal defense factor intestinal alkaline phosphatase. Am J Physiol Gastrointest Liver Physiol 299:G467–G475.
Chen KT, Malo MS, Beasley-Topliffe LK, Poelstra K, Millan JL, Mostafa G, Alam SN, Ramasamy S, Warren HS, Hohmann EL, Hodin RA. 2011. A role for intestinal alkaline phosphatase in the maintenance of local gut immunity. Dig Dis Sci 56:1020–1027.
de Lange CFM, Pluske J, Gong J, Nyachoti CM. 2010. Strategic use of feed ingredients and feed additives to stimulate gut health and development in young pigs. Livest Sci 134:124–134.
Fairbrother JM, Nadeau E, Gyles CL. 2005.
Escherichia coli in postweaning diarrhea in pigs: an update on bacterial types, pathogenesis, and prevention strategies. Anim Health Res Rev 6:17–39.
Gallois M, Oswald IP. 2008. Immunomodulators as efficient alternatives to in-feed antimicrobials in pig production. Arch Zootech 11:15–32.
Goldberg RF, Austen WG, Zhang X, Munene G, Mostafa G, Biswas S, McCormack M, Eberlin KR, Nguyen JT, Tatlidede HS, Warren HS, Narisawa S, Millán JL, Hodin RA. 2008. Intestinal alkaline phosphatase is a gut mucosal defense factor maintained by enteral nutrition. Proc Natl Acad Sci USA 105:3551–3556.
Goldstein DJ, Rogers C, Harris H. 1982. A search for trace expression of placental-like alkaline phosphatase in non-malignant human tissues: demonstration of its occurrence in lung, cervix, testis and thymus. Clin Chim Acta 125:63–75.
Heo JM, Opapeju FO, Pluske JR, Kim JC, Hampson DJ, Nyachoti CM. 2013. Gastrointestinal health and function in weaned pigs: a review of feeding strategies to control post-weaning diarrhoea without using in-feed antimicrobial compounds. J Anim Physiol Anim Nutr (Berl) 97:207–237.
Howe LM. 2000. Novel agents in the therapy of endotoxic shock. Expert Opin Investig Drugs 9:1363–1372.
Hu CH, Xiao K, Song J, Luan ZS. 2013. Effects of zinc oxide supported on zeolite on growth performance, intestinal microflora and permeability, and cytokines expression of weaned pigs. Anim Feed Sci Technol 181:65–71.
Jang IS, Ko YH, Kang SY, Lee CY. 2007. Effect of a commercial essential oil on growth performance, digestive enzyme activity and intestinal microflora population in broiler chickens. Anim Feed Sci Technol 134:304–315.
Kim JC, Hansen CF, Mullan BP, Pluske JR. 2012. Nutrition and pathology of weaner pigs: Nutritional strategies to support barrier function in the gastrointestinal tract. Anim Feed Sci Technol 173:3–16.
Koyama I, Matsunaga T, Harada T, Hokari S, Komoda T. 2002. Alkaline phosphatases reduce toxicity of lipopolysaccharides
in vivo and
in vitro through dephosphorylation. Clin Biochem 35:455–461.
Lackeyram D, Yang C, Archbold T, Swanson KC, Fan MZ. 2010. Early weaning reduces small intestinal alkaline phosphatase expression in pigs. J Nutr 140:461–468.
Lallès JP. 2010. Intestinal alkaline phosphatase: Multiple biological roles in maintenance of intestinal homeostasis and modulation by diet. Nutr Rev 68:323–332.
Lallès JP. 2014. Intestinal alkaline phosphatase: Novel functions and protective effects. Nutr Rev 72:82–94.
Levkut M, Marcin A, Revajová V, Lenhardt L, Danielovič I, Hecl J, Blanár J, Levkutová M, Pistl J. 2011. Influence of oregano extract on the intestine, some plasma parameters and growth performance in chickens. Acta Vet Brno 61:215–225.
Levkut M, Marcin AL, Lenhardt L’, Porvaz P, Revajová V, Šoltysová B, Blanár J, Ševčíková Z, Pistl J. 2010. Effect of sage extract on alkaline phosphatase, enterocyte proliferative activity and growth performance in chickens. Acta Vet Brno 79:177–183.
Li X, Yin J, Li D, Chen X, Zang J, Zhou X. 2006. Dietary supplementation with zinc oxide increases Igf-I and Igf-I receptor gene expression in the small intestine of weanling piglets. J Nutr 136:1786–1791.
Malo MS, Moaven O, Muhammad N, Biswas B, Alam SN, Economopoulos KP, Gul SS, Hamarneh SR, Malo NS, Teshager A, Mohamed MM, Tao Q, Narisawa S, Millan JL, Hohmann EL, Warren HS, Robson SC, Hodin RA. 2014. Intestinal alkaline phosphatase promotes gut bacterial growth by reducing the concentration of luminal nucleotide triphosphates. Am J Physiol Gastrointest Liver Physiol 306:G826–G838.
Malo MS, Biswas S, Abedrapo MA, Yeh L, Chen A, Hodin RA. 2006. The pro-inflammatory cytokines, IL-1beta and TNF-alpha, inhibit intestinal alkaline phosphatase gene expression. DNA Cell Biol 25:684–695.
Martin L, Pieper R, Schunter N, Vahjen W, Zentek J. 2013. Performance, organ zinc concentration, jejunal brush border membrane enzyme activities and mRNA expression in piglets fed with different levels of dietary zinc. Arch Anim Nutr 67:248–261.
Martínez-Moya P, Ortega-Gonzalez M, Gonzalez R, Anzola A, Ocon B, Hernandez-Chirlaque C, Lopez-Posadas R, Suarez MD, Zarzuelo A, Martinez-Augustin O, Sanchez de Medina F. 2012. Exogenous alkaline phosphatase treatment complements endogenous enzyme protection in colonic inflammation and reduces bacterial translocation in rats. Pharmacol Res 66:144–153.
McGhee JR, Lamm ME, Strober W. 1999. Mucosal immune responses: an overview. Mucosal Immunology. 2nd EdOgra PL, Mestecky J, Lamm ME, editorsAcademic Press; San Diego, CA, USA: p. 485–506.
Moss AK, Hamarneh SR, Mohamed MM, Ramasamy S, Yammine H, Patel P, Kaliannan K, Alam SN, Muhammad N, Moaven O, Teshager A, Malo NS, Narisawa S, Millán JL, Warren HS, Hohmann E, Malo MS, Hodin RA. 2013. Intestinal alkaline phosphatase inhibits the proinflammatory nucleotide uridine diphosphate. Am J Physiol Gastrointest Liver Physiol 304:G597–604.
Mussá T, Ballester M, Silva-Campa E, Baratelli M, Busquets N, Lecours MP, Dominguez J, Amadori M, Fraile L, Hernández J, Montoya M. 2013. Swine, human or avian influenza viruses differentially activates porcine dendritic cells cytokine profile. Vet Immunol Immunopathol 154:25–35.
Oshiumi H, Matsumoto M, Funami K, Akazawa T, Seya T. 2003. TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction. Nat Immunol 4:161–167.
Perez R, Stevenson F, Johnson J, Morgan M, Erickson K, Hubbard NE, Morand L, Rudich S, Katznelson S, German JB. 1998. Sodium butyrate upregulates Kupffer cell PGE2 production and modulates immune function. J Surg Res 78:1–6.
Pié S, Lallès JP, Blazy F, Laffitte J, Sève B, Oswald IP. 2004. Weaning is associated with an upregulation of expression of inflammatory cytokines in the intestine of piglets. J Nutr 134:641–647.
Poelstra K, Bakker WW, Klok PA, Kamps JA, Hardonk MJ, Meijer DK. 1997a. Dephosphorylation of endotoxin by alkaline phosphatase
in vivo. Am J Pathol 151:1163–1169.
Poelstra K, Bakker WW, Klok PA, Hardonk MJ, Meijer DK. 1997b. A physiologic function for alkaline phosphatase: endotoxin detoxification. Lab Invest 76:319–327.
Prakash UN, Srinivasan K. 2010. Beneficial influence of dietary spices on the ultrastructure and fluidity of the intestinal brush border in rats. Br J Nutr 104:31–39.
Roselli M, Finamore A, Garaguso I, Britti MS, Mengheri E. 2003. Zinc oxide protects cultured enterocytes from the damage induced by
Escherichia coli. J Nutr 133:4077–4082.
Sang Y, Yang J, Ross CR, Rowland RR, Blecha F. 2008. Molecular identification and functional expression of porcine Toll-like receptor (TLR) 3 and TLR7. Vet Immunol Immunopathol 125:162–167.
Shelton NW, Tokach MD, Nelssen JL, Goodband RD, Dritz SS, DeRouchey JM, Hill GM. 2011. Effects of copper sulfate, tri-basic copper chloride, and zinc oxide on weanling pig performance. J Anim Sci 89:2440–2451.
Shimosato T, Tohno M, Kitazawa H, Katoh S, Watanabe K, Kawai Y, Aso H, Yamaguchi T, Saito T. 2005. Toll-like receptor 9 is expressed on follicle-associated epithelia containing M cells in swine Peyer's patches. Immunol Lett 98:83–89.
Shinkai H, Tanaka M, Morozumi T, Eguchi-Ogawa T, Okumura N, Muneta Y, Awata T, Uenishi H. 2006a. Biased distribution of single nucleotide polymorphisms (SNPs) in porcine Toll-like receptor 1 (TLR1), TLR2, TLR4, TLR5, and TLR6 genes. Immunogenetics 58:324–330.
Shinkai H, Muneta Y, Suzuki K, Eguchi-Ogawa T, Awata T, Uenishi H. 2006b. Porcine Toll-like receptor 1, 6, and 10 genes: complete sequencing of genomic region and expression analysis. Mol Immunol 43:1474–1480.
Sussman NL, Eliakim R, Rubin D, Perlmutter DH, DeSchryver-Kecskemeti K, Alpers DH. 1989. Intestinal alkaline phosphatase is secreted bidirectionally from villous enterocytes. Am J Physiol 257:1 Pt 1G14–G23.
Takeda K, Akira S. 2004. TLR signaling pathways. Semin Immunol 16:3–9.
Taras D, Vahjen W, Macha M, Simon O. 2006. Performance, diarrhea incidence, and occurrence of
Escherichia coli virulence genes during long-term administration of a probiotic Enterococcus faecium strain to sows and piglets. J Anim Sci 84:608–617.
Tohno M, Shimosato T, Kitazawa H, Katoh S, Iliev ID, Kimura T, Kawai Y, Watanabe K, Aso H, Yamaguchi T, Saito T. 2005. Toll-like receptor 2 is expressed on the intestinal M cells in swine. Biochem Biophys Res Commun 330:547–554.
Tohno M, Shimosato T, Moue M, Aso H, Watanabe K, Kawai Y, Yamaguchi T, Saito T, Kitazawa H. 2006. Toll-like receptor 2 and 9 are expressed and functional in gut-associated lymphoid tissues of presuckling newborn swine. Vet Res 37:791–812.
Tucci FM, Thomaz MC, Nakaghi LSO, Hannas MI, Scandolera AJ, Budiño FEL. 2011. The effect of the addition of trofic agents in weaned piglet diets over the structure and ultra-structure of small intestine and over performance. Arq Bras Med Vet Zootec 63:931–940.
Tuin A, Huizinga-Van der Vlag A, van Loenen-Weemaes AM, Meijer DK, Poelstra K. 2006. On the role and fate of LPS-dephosphorylating activity in the rat liver. Am J Physiol Gastrointest Liver Physiol 290:G377–G385.
Uenishi H, Shinkai H. 2009. Porcine Toll-like receptors: the front line of pathogen monitoring and possible implications for disease resistance. Dev Comp Immunol 33:353–361.
Uysal G, Sökmen A, Vidinlisan S. 2000. Clinical risk factors for fatal diarrhea in hospitalized children. Indian J Pediatr 67:329–333.
Vaishnava S, Hooper LV. 2007. Alkaline phosphatase: keeping the peace at the gut epithelial surface. Cell Host Microbe 2:365–367.
Weber TE, Kerr BJ. 2008. Effect of sodium butyrate on growth performance and response to lipopolysaccharide in weanling pigs. J Anim Sci 86:442–450.
Yamamoto M, Sato S, Mori K, Hoshino K, Takeuchi O, Takeda K, Akira S. 2002. Cutting edge: A novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling. J Immunol 169:6668–6672.