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Effect of Helminthiasis on Zinc Metabolism |
L. M. Musalia, P. Aggett |
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Abstract |
The effect of helminthiasis on zinc metabolism was monitored using endogenous 65Zn after intraperitoneal injection of 1 g of 65Zn as zinc chloride. In the first experiment zinc turnover was investigated in 18 male weanling rats, which were randomly divided into 3 groups. One group was infected with 73 third stage larvae of Nippostrongylus brasiliensis per gram body weight ; the other groups were the pair-fed and ad lib-fed controls. The route of loss of zinc was investigated in the second experiment with the same design using 18 animals with a lower dose of infection (33 larvae per gram body weight). The biological half life of endogenous 65Zn was lower (p<0.05) in the infected group as compared to the controls. In the later phase of infection (9th to 16th day) there was reduced retention of 65Zn and increased loss (p<0.05) of 65Zn from the body though urine and faeces. It was concluded that infection of N. brasiliensis was accompanied by increased loss of endogenous Zn through faeces and urine. |
Keywords:
Helminthiasis; Nippostrongylus brasiliensis; Rats; Zinc; Feed Intake |
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