|
Effect of Arachidonic Acid on Production of Laminin and Connexin of Granulosa Cells from Chicken Pre-hierarchical Follicles |
|
Yanmei Jin, Tu Quang Tan, Caiqiao Zhang* |
|
|
Correspondence:
Caiqiao Zhang,
|
|
|
|
|
|
| Abstract |
|
Arachidonic acid (AA) is a polyunsaturated fatty acid that is a normal constituent of membrane lipids in animal cells. In addition to its role as a precursor of prostaglandins, AA itself may play an important role in the regulation of cell function. The effect of AA on functions of granulosa cells was investigated in pre-hierarchical small yellow follicles of laying hens. Immuno-cytochemical staining showed that AA (10-7-10-5 M) increased the expression of the extracellular matrix glycoprotein laminin, gap junction connexin 43 and protein kinase C (PKC). Therefore, mediated by the PKC signal pathway, AA may regulate the intercellular communication of granulosa cells and follicular development by increasing the expression of laminin and connexin. |
| Keywords:
Granulosa Cell; Arachidonic Acid; Laminin; Connexin 43; Chicken |
|
PDF Links
Full text via DOI
Download Citation
