Mapping Quantitative Trait Loci with Various Types of Progeny from Complex Pedigrees

Lee, C.; Wu, X. L.

doi:2001.14.11.1505

Article

Animal Breeding and Genetics

Asian-Australasian Journal of Animal Sciences 2001;14(11): 1505-1510.
https://doi.org/10.5713/ajas.2001.1505 Published online November 1, 2001.

Mapping Quantitative Trait Loci with Various Types of Progeny from Complex Pedigrees

C. Lee, X. L. Wu

Abstract

A method for mapping quantitative trait loci (QTL) was introduced incorporating the information of mixed progeny from complex pedigrees. The method consisted of two steps based on single marker analysis. The first step was to examine the marker-trait association with a mixed model considering common environmental effect and reversed QTL-marker linkage phase. The second step was to estimate QTL effects by a weighted least square analysis. A simulation study indicated that the method incorporating mixed progeny from multiple generations improved the accuracy of QTL detection. The influence of within-genotype variance and recombination rate on QTL analysis was further examined. Detecting a QTL with a large within-genotype variance was more difficult than with a small within-genotype variance. Most of the significant marker-QTL association was detectable when the recombination rate was less than 15%.

Keywords: Complex Pedigree; Mixed Models; QTL; Recombination Rate