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Asian-Australas J Anim Sci > Accepted
doi: https://doi.org/10.5713/ajas.16.0824    [Accepted]
Effect of sodium butyrate on performance, immune status, microarchitecture of small intestinal mucosa and lymphoid organs in broiler chickens
Arbab Sikandar*, Hafsa Zaneb1,*, Muhammad Younus2, Saima Masood1, Farina Khattak1, Asim Aslam3, Saima Ashraf1, Muhammad Shahbaz Yousaf4, Habib Rehman4
Department of Basic Sciences, College of Veterinary and Animal Sciences (CVAS), Jhang 35200, sub-campus, University of Veterinary and Animal Sciences (UVAS), Lahore, Pakistan
1Department of Anatomy and Histology, University of Veterinary and Animal Sciences, 54000, Lahore, Pakistan
2Department of Pathobiology, College of Veterinary and Animal Sciences, Jhang 35200, sub-campus, University of Veterinary and Animal Sciences, Lahore, Pakistan
3Department of Pathology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan
4Department of Physiology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan
* Corresponding Author: Arbab Sikandar ,Tel: +92-47-7671263, Fax: +92-47-7671262, Email: arbab.sikandar@uvas.edu.pk / Hafsa Zaneb ,Tel: +92-42-9921-1449(238), Fax: 0477671262, Email: hafsa.zaneb@uvas.edu.pk
Received: October 25, 2016;  Revised: November 22, 2016.  Accepted: October 25, 2016.  Published online January 13, 2017.

ABSTRACT
Objective:
This study aimed to examine the effect of sodium butyrate (SB) on growth performance, immune status, organs weights, and microarchitecture of lymphoid organs and small intestine.
Method:
A total of 120, 1-d-old broiler chicks were distributed into the following four treatment groups: corn-soy based basal diet (BD) without supplement (control), or the same BD supplemented with 0.1g/kg zinc bacitracin (ZnB), 0.5g/kg SB (SB-0.5) or 1.0 g/kg SB (SB-1), respectively. Six birds /group were killed on d-21 and d-35, and samples were collected.
Results:
Cell-mediated immune response at 48 hr post-Phytohemagglutinin-P injection, and antibody titer against ND vaccine and sheep RBCs on d-35 was noted higher (p < 0.05) in SB-1 compared to ZnB and control. Lower (p < 0.05) FCR was attained by the supplemented groups. Thymus and spleen weighed more (p < 0.05) in SB-1, and bursa registered more (p < 0.05) weight in both SB groups compared to control. On d-21, areas of thymus medulla and spleen germinal centers were noted higher (p < 0.05) in SB-1 group. The villus height (VH) and villus surface area (VSA) increased (p < 0.05) in duodenum and jejunum in both SB groups on d-21, and in SB-1 on d-35, respectively compared to ZnB and control. On d-21, number of goblet cells containing mucins of acidic nature increased (p < 0.05) in all the segments of small intestines in SB-1 group compared to control, and on d-35 in ileum compared to other groups.
Conclusion:
In conclusion, sodium butyrate improved growth performance and immunity as well as modulated morphology of lymphoid organs and gut mucosa in broiler chickens.
Keywords: Organic acid; Poultry; AGP; mucosa; IEL; goblet cells
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