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Asian-Australas J Anim Sci > Accepted
doi: https://doi.org/10.5713/ajas.16.0562    [Accepted]
Genome Scan Linkage Analysis Identifies a Major QTL for Fatty Acid Composition in longissimus dorsi Muscle in an F2 Intercross between Landrace and Korean Native Pigs
Hee-Bok Park, Sang-Hyun Han1,3, Chae-Kyung Yoo2, Jae-Bong Lee4, Ji-Hyang Kim, Kwang-Soo Baek, Jun-Kyi Son, Sang-Min Shin, Hyun-Tae Lim2,5,*, In Cheol Cho*
National Institute of Animal Science, RDA, Jeju, Korea
1Educational Science Research Institute, Jeju National University, Jeju, Korea
2Institute of Agriculture and Life Sciences, Gyeongsang National University, Jinju, Korea
3Educational Science Research Institute, Jeju National University, Jeju, Korea
4Korea Zoonosis Research Institute, Chonbuk National University, Iksan, Korea
5Department of Animal Sciences, College of Agriculture and Life Sciences, Gyeongsang National University, Jinju, Korea
* Corresponding Author: Hyun-Tae Lim ,Tel: +82-62-754-5710, Fax: +82-64-754-5713, Email: choic4753@korea.kr / In Cheol Cho ,Tel: +82-62-754-5710, Fax: +82-64-754-5713, Email: choic4753@korea.kr
Received: July 22, 2016;  Revised: October 25, 2016.  Accepted: December 29, 2016.  Published online January 2, 2017.

ABSTRACT
Objective:
This study was conducted to locate quantitative trait loci (QTL) influencing fatty acid (FA) composition in a large F2 intercross between Landrace and Korean native pigs.
Method:
Eighteen FA composition traits were measured in more than 960 F2 progeny. All experimental animals were genotyped with 165 microsatellite markers located throughout the pig autosomes.
Results:
We detected 112 QTLs for the FA composition; Forty seven QTLs reached the genome-wide significant threshold. In particular, we identified a cluster of highly significant QTLs for FA composition on SSC12. QTL for polyunsaturated fatty acid (PUFA) on pig chromosome 12 (F-value = 97.2 under additive and dominance model, nominal P-value 3.6×10-39) accounted for 16.9% of phenotypic variance. In addition, four more QTLs for C18:1, C18:2, C20:4, and monounsaturated fatty acids (MUFAs) on the similar position explained more than 10% of phenotypic variance.
Conclusion:
Our findings of a major QTL for fatty acid composition presented here could provide helpful information to locate causative variants to improve meat quality traits in pigs.
Keywords: Fatty acid; Quantitative trait locus; Genome-wide linkage analysis; Landrace; Korean native pigs
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